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Small Molecules

Pharmacokinetic (PK) Assessment

Pharmacokinetics is the study of the time course of a new chemical entity introduced into the body by different routes of administration e.g. intravenous, oral, subcutaneous etc. It is important to quantitatively measure drug concentrations at site of action to understand drug effect in the body. Custom LC-MS/MS methods are designed to measure concentrations of new chemical entities in plasma or other biological matrices. LC - triple quadrupole mass spectrometers are used. General PK calculations can be performed.


We perform microsome incubations for metabolite profiling and metabolite identification. In vivo metabolite profiling could also be performed using biological matrices collected during non clinical or clinical studies (e.g. urine).  Full scan and fragmentation of metabolites and parent is performed to assist in structure elucidation. Metabolite identification is performed by interpreting high resolution MS data and low resolution MS/MS fragmentation. Data analysis and metabolite ID data report is prepared upon completion of experiment.

Targeted Metabolomics

We perform targeted metabolomics application of metabolomics analysis to specific classes of compounds. Custom developed LC-MS methods are designed to selectively collect information regarding group(s) of related metabolites extracted from biological fluids. Metabolite identification is performed by interpreting high resolution MS data and low resolution MS/MS fragmentation data (if applicable), searching against databases and comparing with authentic compounds.