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Pharmacokinetic (PK) Assessment

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Pharmacokinetics is the study of the time course of a new chemical entity introduced into the body by different routes of administration e.g. intravenous, oral, subcutaneous etc. It is important to quantitatively measure drug concentrations at site of action to understand drug effect in the body. Custom LC-MS/MS methods are designed to measure concentrations of new chemical entities in plasma or other biological matrices. LC - triple quadrupole mass spectrometers are used. General PK calculations can be performed.

Basic principles of pharmacokinetics Toxicologic Pathology
Benet LZ1, Zia-Amirhosseini P.
1995; Mar-Apr;23(2):115-123