We perform microsome incubations for metabolite profiling and metabolite identification. In vivo metabolite profiling can also be performed using biological matrices collected during non-clinical or clinical studies (e.g. urine). Full scan and fragmentation of metabolites and parent are performed to assist in structure elucidation. Metabolite identification is performed by interpreting high resolution MS data and low resolution MS/MS fragmentation. Data analysis and metabolite ID data reports are prepared upon completion of experiment.
Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry. Chemical Research in|
Toxicology, Alvarez-Sanchez R1, Montavon F, Hartung T, Pähler A. 2006 Aug;19(8):1106-16