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Instruments

Instruments at SUMS
Front view of a Xevo TQ-XS mass spectrometer and Acquity UPLC Waters Xevo TQ-XS

The Xevo TQ-XS is our newest triple quad, providing cutting-edge targeted quantitation capabilities with both analytical and microflow UPLC separations. The Xevo was acquired in 2019 with federal funding that must be acknowledged: "This work utilized the Xevo TQ-XS mass spectrometer system that was purchased with funding from National Institutes of Health Shared Instrumentation grant S10OD026962."

Agilent 7890/5975 GC/MS (open access)

The Agilent GC/MS is a single quadrupole instrument with electron ionization (EI) that generates "fingerprint" fragment spectra for volatile compounds.  The GC/MS runs under ChemStation open access software, and trained open access users select from a menu of standard methods to analyze their samples.

Bruker Microflex MALDI-TOF (open access)

The Microflex LRF is specialized for protein, peptide, and polymer analysis. This MALDI-TOF instrument can be operated in a linear mode for high mass accuracy characterization, or in a reflector mode to achieve enhanced resolution.

Bruker micrOTOF-Q II LC/MS

The Bruker micrOTOF-Q II is a benchtop Q-Tof, applied to a variety of applications such as small molecule accurate mass determination (HRMS), intact protein analysis including antibodies, peptide mapping, and other custom projects. This system is operated with an Agilent 1260 UPLC and includes an inline diode array detector and ESI source.

Bruker Scion TQ GC/MS

The Scion GC triple quad is applied to targeted trace-level analysis of metabolites and other small molecules.  The electron ionization (EI) combines with MS/MS capability for outstanding selectivity.  Samples are often derivatized for compatibility with GC/MS.

Shimadzu 8030 LC/MS Shimadzu 8030 LC/MS

The Shimadzu 8030 triple quadrupole mass spectrometer is a workhorse for targeted quantitation applications.

Thermo Exactive Orbitrap and Waters Acquity UPLC Thermo Exactive Orbitrap LC/MS (open access)

The Thermo Exactive benchtop Orbitrap operates with a Waters Acquity UPLC and generates high resolution, high mass accuracy full MS data.  It is available to advanced open access users for reversed-phase and HILIC LC/MS applications.

Thermo LTQ XL, Agilent 1100 LC/MS Thermo LTQ XL LC/MS

The LTQ XL ion trap mass spectrometer with Agilent 1100 HPLC system is used for a variety of studies including metabolite identification, stability testing, degradation products, and high-abundance quantitation.

Thermo LTQ-Orbitrap Elite MS and Waters nanoAcquity UPLC Thermo LTQ-Orbitrap Elite nanoLC/MS

The LTQ-Orbitrap Elite with Waters nanoAcquity is broadly used for proteomic applications.  The Elite was acquired with federal funding that must be acknowledged: "This work utilized the LTQ-Orbitrap mass spectrometer system that was purchased with funding from National Institutes of Health Shared Instrumentation grant S10RR027425."

Thermo Orbitrap Fusion and Waters M-Class nanoLC/MS Thermo Orbitrap Fusion nanoLC/MS

The Thermo Orbitrap Fusion Tribrid mass spectrometer and Waters M-Class Acquity nanoUPLC is a versatile platform. This platform features sequential acquisition capabilities and multiple fragmentation types, enabling complex, in depth proteomic experiments. 

M-Class Acquity UPLC and Q-Exactive HFX mass spectrometer Thermo QE-HFX

The HFX is our newest addition to the proteomics resource.  It offers the fastest scanning rate of our Orbitraps, which improves proteomic depth for discovery applications, and integrates well with targeted applications such as parallel reaction monitoring (PRM).

Thermo Accela/Vantage LC/MS Thermo Vantage LC/MS

The Vantage triple quad and Accela UPLC/MS specializes in quantitative work and selective assays of targeted analytes, including metabolites and other small molecules, and peptides from complex matrices such as serum, tissue, cell culture, and other biological sources.

Waters (Micromass) Quattro Premier LC/MS Waters Quattro Premier LC/MS

The Micromass (now Waters) Quattro Premier triple quadrupole operates with an Agilent 1100 HPLC and specializes in quantitative work and selective of targeted analytes including metabolites and other small molecules, and peptides from complex matrices such as serum, tissue, cell culture, and other biological sources.