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Pharmacokinetic (PK) Assessment

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Pharmacokinetics is the study of the time course of a chemical entity introduced into the body by various routes of administration e.g. intravenous, oral, subcutaneous. It is important to quantitatively measure drug concentrations at the site of action to understand the drug effect in the body. Custom LC-MS/MS methods are designed to measure concentrations of new chemical entities in plasma or other biological matrices. LC-triple quadrupole mass spectrometers are used. General PK calculations can be performed.

Basic principles of pharmacokinetics. Toxicologic Pathology,Benet LZ1, Zia-Amirhosseini P. 1995; Mar-Apr;23(2):115-123