2018 SUMS-RAS

Thursday, October 4, 2018

A symposium for users of mass spectrometry resources as well as those interested in finding out more about applications of the technology. The Stanford University Mass Spectrometry Research Applications Symposium (SUMS-RAS) is an annual opportunity for Stanford and community scientists to meet, mingle, and learn about ongoing mass spec-related research, new developments, and research resources.

Keynote: Carlito Lebrilla, PhD Professor, Dept. of Chemistry, UC Davis Comprehensive methods for characterizing glycosylation and their implications to diseases and nutrition
Cells are covered by a highly glycosylated membrane called the glycocalyx. Cells can also secrete glycans as glycoproteins and as free glycans. The glycocalyx has been known to alter during cell development and transition to diseases. Characterizing glycocalyx has been particularly difficult as the number and types of glycans are both abundant and structurally diverse. We have developed tools for structurally elucidating and quantitating cellular glycosylation. These methods include the analysis N- and O-glycans in glycoproteins, and glycans on glycolipids. Mass spectrometry (MS) has been at the center of these methods. Liquid chromatography coupled to MS provides profiles with hundreds and thousands of compounds providing extensive view of alteration in glycosylation during disease progression in cancer and autoimmune diseases. The same methods are used to examine changes in glycosylation during lactation in milk and as milk interacts with the gut microbiota. These methods are providing unprecedented insights into the critical role of glycans in cellular function leading to potentially more specific biomarkers for diseases and potential new targets for therapeutics. They are also elucidating the critical roles glycans play in diseases and nutrition.

Keynote: Carlito Lebrilla, PhD
Professor, Dept. of Chemistry, UC Davis

Comprehensive methods for characterizing glycosylation and their implications to diseases and nutrition

Cells are covered by a highly glycosylated membrane called the glycocalyx. Cells can also secrete glycans as glycoproteins and as free glycans. The glycocalyx has been known to alter during cell development and transition to diseases. Characterizing glycocalyx has been particularly difficult as the number and types of glycans are both abundant and structurally diverse. We have developed tools for structurally elucidating and quantitating cellular glycosylation. These methods include the analysis N- and O-glycans in glycoproteins, and glycans on glycolipids. Mass spectrometry (MS) has been at the center of these methods. Liquid chromatography coupled to MS provides profiles with hundreds and thousands of compounds providing extensive view of alteration in glycosylation during disease progression in cancer and autoimmune diseases. The same methods are used to examine changes in glycosylation during lactation in milk and as milk interacts with the gut microbiota. These methods are providing unprecedented insights into the critical role of glycans in cellular function leading to potentially more specific biomarkers for diseases and potential new targets for therapeutics. They are also elucidating the critical roles glycans play in diseases and nutrition.

CALL FOR ABSTRACTS
Share your mass spec-related research at SUMS-RAS 2018!

Present a scientific poster, and enter the poster competition. Posters will be displayed all day, and featured in an expanded morning poster session fueled by refreshments. Poster Competition winners will be awarded a $50 gift card at the closing reception! (Note: Lightning Talk entries are now closed)

PROGRAM

Time:	Activity:
8:00 am	Breakfast
	Exhibits
8:30 am	Welcome, Scientific Session I
	Advances in coffee flavor preservation Matthew Roberts, Comet Technologies
	Deep profiling of the human protein arginine methyl-transferase enzyme class interactome Jeremy O'Connell, PhD, Dept. of Microbiology & Immunology, Stanford University School of Medicine
	The role of dopamine in the collective regulation of foraging in harvester ants Daniel Friedman, PhD, Dept. of Biology, Stanford University
9:45 am	Poster Session
10:45 am	Sponsor Seminars [Abstracts]
	Semi-Automated Sample Prep for Quantitative Phosphoproteomics using the AssayMAP Platform Randy Bolger, PhD, Manager - Workflow Solutions, Americas, Agilent Technologies, Inc.
	Proteomic Applications of Sensitivity and Speed with the timsTOF Pro and PASEF Chris Adams, PhD, West Coast Proteomics Manager, Bruker Daltonics
	New Software for Structural Biology by Mass Spectrometry Marshall Bern, PhD, Vice President, Protein Metrics
	New Trends and Solutions in -Omics Suraj Dhungana, PhD, Biomedical Research Market Development Manager, Waters Corporation
11:45 am	Keynote: Comprehensve methods for characterizing glycosylation and their implications to diseases and nutrition Professor Carlito Lebrilla, Dept. of Chemistry, University of California, Davis
12:45 pm	Lunch
1:45 pm	Scientific Session II
	What if mass spectrometry said there was no negative control for antibiotic exposure? Eric Jorge Nelson, MD, PhD, Dept. of Environmental & Global Health, University of Florida
2:20 pm	Lightning Talks
	A mucin-specific protease improves mass spectrometric analysis of mucin-type O-glycoproteins Stacy A. Malaker, PhD, Dept. of Chemistry, Stanford University
	Serine metabolism in breast cancer metastasis Albert Li, Dept. of Medicine - Cancer Biology, Stanford University School of Medicine
	Efficient proximity labeling in living cells and organisms with TurboID Tess Branon, PhD, Dept. of Genetics, Stanford University School of Medicine
	Ambient ionization mass spectrometry imaging for prognostic metabolic signatures in cancer tissues and biopsies Vijaya Lakshmi Kanchustambham, PhD, Dept. of Chemistry, Stanford University
	Longitudinal multi-omics profiling in response to exercise in healthy and prediabetic individuals Kevin Contrepois, PhD, Dept. of Genetics, Stanford University School of Medicine
3:15 pm	Reception
3:45 pm	Poster Competition Awards Sponsor Raffle